• Basel

Site 1201 F. Hoffmann-La Roche AG

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von: 1201 F. Hoffmann-La Roche AG | Ort: Basel | Referenz: f685a497-606e-43aa-91d7-cbf7ea415bc5

The Position

In Roches Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world's toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located in ADME, a chapter within Global Pharmaceutical Sciences, where the fate of new chemical entities and biologics is a primary focus. The ADME Chapter works throughout all stages of compound development, from lead optimization to candidate selection, all clinical development phases to the filing of new drug applications. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.

Role Mission

Depending on your background, you will either support biotransformation, enzymology or transport to assess the drug metabolism and disposition of our new small molecule and biologics drug research and development candidates.

Your Impact

  • The responsibility of the job encompasses the set-up, validation and application of state-of-the-art approaches to assess the biotransformation, enzymology or transport of our small molecule drug candidates besides new modalities upon necessity.

  • Projects in scope range from early discovery up to the regulatory submission stage in accordance with the health authority guidelines.

  • You will design experimental strategies, run and/or monitor the appropriate experiments, working with state-of-the-art LC-MS equipment.

Your Profile

You hold a PhD in chemistry, biochemistry or a related relevant disciplineand have in-depth knowledge and several years of practical experience (preferably industrial) in the area of drug discovery and development ADME:

  • in structure elucidation of metabolites through the generation and interpretation of high-resolution mass spectra or

  • in the area of drug metabolism, enzyme inhibition/induction and in silico prediction methodologies (e.g. PBPK) for human PK prediction and DDI risk assessment or

  • in the area of active drug transporter research, including DDI risk assessment and regulatory requirements or

  • in plasma protein binding (PPB) for discovery and clinical phases.

Our commitment

Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.

We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way</a>; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

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